Greencastle is a city in Greencastle Township, Putnam County, Indiana, United States, and the county seat of Putnam County. It was founded in 1821 by Ephraim Dukes on a land grant. He named the settlement for his hometown of Greencastle, Pennsylvania. Greencastle was a village or town operating under authority of the Putnam County commissioners until March 9, 1849, when it became a town by special act of the local legislature. Greencastle, Indiana, officially became a city after an election held on July 8, 1861. The first mayor of Greencastle was E. R. Kercheval, a member of the Freemason Temple Lodge #47. The city became the county seat of Putnam County. The population was 10,326 at the 2010 census. It is located near Interstate 70 approximately halfway between Terre Haute and Indianapolis in the west-central portion of the state. Greencastle is well known as being the location of DePauw University.